Ochopee barely qualifies as a place. It is a gap in the swamp on the Tamiami Trail, with a few buildings, a produce stand and a very small post office that has a claim to be the smallest in the United States. The building was originally a tool shed for a tomato farm's irrigation pipes, and after a fire destroyed the earlier store and post office in the 1950s it was pressed into service as a replacement, and it has been delivering letters from the same tiny room ever since. People stop to photograph it, buy a postcard and stamp it on the spot, and that is more or less the point of the visit.
What surrounds it is much bigger. Big Cypress National Preserve covers hundreds of thousands of acres of cypress swamp, pine islands and prairie, and the road passes through it in a straight line with a canal beside the verge. The preserve is the home of the Florida panther, one of the rarest large cats in North America, though you are more likely to see alligators, anhingas and herons. Road signs warn of panther crossings, and speed limits are lower at night for a reason. Ochopee's name comes from a Seminole word usually given as meaning big field, which fits the open, flat view.
The riding is straight, flat and warm, with tropical air that smells of wet vegetation and sometimes of smoke from controlled burns. The dry winter months are by far the best. In summer the heat and humidity are heavy, there are thunderstorms most afternoons, and mosquitoes can be thick enough to make the stops short. Watch for cars pulling out from airboat and swamp buggy tour places, and for turtles and snakes crossing. The surface is generally good, but there is very little shade and few places to stop.
Practical matters need care. There is no reliable fuel at Ochopee itself, so use Everglades City, a short drive south, or the stations on the Miccosukee reservation and at the Naples end of the road, which is the nearest large place on the west. Pack water and sunscreen, and do not rely on mobile signal. Stone crab season, from mid-October to May, brings a good reason to detour to Everglades City for a plate of claws, if you like that sort of thing, and the trip is a short one.